Understanding Molecular Mechanisms of Adaptation and Improving Health by Optimizing Exercise

Learning How to Get Fit
One of the primary aims of our research program is to understand what types of exercise training is are capable of improving fitness.  We are particularly interested in the intensities of recreational sport and whole body high intensity interval training that are required to improve aerobic capacity and exercise performance.
Understanding Mechanisms to Optimize Exercise
The ability of exercise to improve whole body fitness has been known for decades.  However, the intensity that will elicit the greatest increase in fitness remains unknown.  We are currently conducting a variety of studies aimed at both establishing the optimial training intesnity, and understanding the underlying mechanisms (both metabolic and cardiovascular) that make this intensity optimal.
Molecular Control of Mitochondrial Biogenesis
Much of our research energy is focused on understanding the molcular mechanisms that control mitochondrial content and function in skeletal muscle and adipose tissue.  Specifically we are examining the roles that SIRT1, PGC-1a and mTOR play in inducing mitochondrial biogenesis following a range of pharmacological, nutritional and exercise interventions.
Translating Basic Research from the Lab to the Community
We are also interested in sharing the knowledge we are gaining from our primary research with both the Kingston community and the Canadian population whenever possible.  This translational work takes many forms including media interviews and research conducted in applied settings.  For examples of this work check out the "Outside the Lab" link at the top of the page.

School of Kinesiology and Health Studies
28 Division St.,Queen's University, Kingston, Ontario, Canada. K7L 3N6.
613.533.6000 x79023